Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

Biography

Manveen Bhardwaj is a Doctoral Research Fellow at Panjab University, India

Abstract

Rationale: Alterations in neurotransmitters levels is the main culprit of the epilepsy. With the antioxidant effects, taurine cause the alterations in the Glutamate and GABA levels. But its mechanism of action in epilepsy is still undeciphered. Thus, there exists rationale in preventing the glutamate excitotoxicity by taurine as neuroprotective strategy in pentylenetetrazole (PTZ) induced kindling epilepsy. Objective: Aim of present study is to investigate the neuroprotective role of taurine and its modulation by minocycline (Mino) in the kindling epilepsy. Method: PTZ (40 mg/kg, i.p.) was administered alternatively for 29 days until animal exhibited full motor seizures. Taurine was given orally at a dose of 25, 50 and 100 mg/kg by dissolving it in distilled water once a day 1 h prior to PTZ treatment and minocycline at the dose of 50 and 100 mg/kg and its combination (Taurine 50 mg/kg + Mino50 mg/kg) and (Taurine 100 mg/kg + Mino100 mg/kg) for the period of 29 days. Various neurobehavioral parameters followed by biochemical, mitochondrial respiratory enzyme complexes (I-IV), neurotransmitter examinations (Glutamate, GABA, Serotonin, Dopamine and Norepinephrine) by HPLC and histopathological alterations by haematoxylin and eosin stain were assessed. Results: PTZ administration significantly impaired the cognitive performance in the morris water maze (MWM) performance test, increased the seizure score, caused oxidative stress, mitochondrial dysfunctioning and also caused alterations in the neurotransmitter levels and in the histopathology of hippocampus and cortex. Treatment with the taurine (25, 50 and 100 mg/kg), minocycline (50 and 100 mg/kg) for 29 days significantly improved the seizure score, reduced AChE activity, oxidative damage (reduced LPO, nitrite level and elevate the SOD, catalase and GSH levels) and also restored the mitochondrial complexes (Complex I, II and IV) and improved the neurotransmitter levels (Glutamate, GABA, Serotonin, Dopamine and Norepinephrine). Combination of taurine with minocycline showed more significant effects as compared to the per se effect. Further, histopathological alterations showed the significant improvement effects in the combination of taurine with minocycline. Conclusion: Taurine when combined with minocycline show the neuroprotection by decreasing the glutamate excitotoxicity against the PTZ induced kindling epilepsy.

Special Issues
All accepted abstracts will be published in respective Allied Academies Journals.
Abstracts will be provided with Digital Object Identifier by

Allied Academies Global Conference Directory

Mail us at

For Program Enquiry
toxicology@alliedconferences.org
To Secure your slot
toxicology@alliedmeetings.com
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.

Insurance

Registration fees do not include insurance of any kind.

Transportation

Please note that any (or) all transportation and parking is the responsibility of the registrant.

Press/Media

Press permission must be obtained from Allied Academies Conferences Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party nonprofit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact
toxicology@alliedconferences.org
to request a personalized letter of invitation.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to contact@alliedacademies.com

Cancellation Policy

If Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to contact@alliedacademies.com . Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference. The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  1. Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  2. Within 60-30 days of Conference: Eligible for 50% of payment Refund
  3. Within 30 days of Conference: Not eligible for Refund
  4. E-Poster Payments will not be refunded

Accommodation Cancellation Policy

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.
Copyright © 2018-2019 Allied Academies, All Rights Reserved.