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Yuri E Dubrova was born in Kiev and spent his school years there. He obtained a BSc degree in Biology at Kiev State University and a PhD in Genetics at N.I. Vavilov Institute of General Genetics in Moscow. He then undertook a number of research projects in population genetics there. In 1994 he moved to the Department of Genetics University of Leicester to study the genetic effects of exposure to ionising radiation and chemical mutagens in mammals. Working there, he has developed a number of sensitive approaches for monitoring mutation induction in the mammalian germline. Analysing mutation rates at minisatellite loci in four cohorts of irradiated families from Belarus, Ukraine, Kazakhstan and Russia he obtained the first experimental evidence for radiation-induction of human germline mutation. Using another class of tandem repeat DNA loci, he analysed the pattern of mutation induction in the germline of male mice exposed to a variety of mutagens, including ionising radiation, alkylating agents and anticancer drugs. He has recently analysed the genome-wide effects of exposure to ionising radiation on mutation induction in the mouse germline.
Analysis of Germline Mutation Induction in Humans and Mice Following Exposure to Ionising Radiation, Chemical Mutagens and Some Anticancer Drugs